To the Editor We considered very interesting the article by Egeberg et al1 in JAMA Neurology demonstrating that rosacea constitutes an independent risk factor for Parkinson disease (PD). Clinically, rosacea is characterized by the features of neurogenic inflammation. The participation of the sensory and/or autonomic nervous system in the pathogenesis of the disease has been confirmed with the use of immunohistochemistry techniques.2 Interestingly, dysregulation of mediators and receptors implicated in neurovascular and neuroimmune communication has been proven to be present even at early stages of rosacea.
Alexoudi A, Alexoudi I, Gatzonis S. Association Between Rosacea and Parkinson Disease. JAMA Neurol. 2016;73(9):1159. doi:10.1001/jamaneurol.2016.2321