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Comment & Response
September 2016

Association Between Rosacea and Parkinson Disease—Reply

Author Affiliations
  • 1Department of Dermatology and Allergy, Herlev and Gentofte University Hospital, University of Copenhagen, Hellerup, Denmark
JAMA Neurol. 2016;73(9):1159-1160. doi:10.1001/jamaneurol.2016.1864

In Reply In their commentary, He et al correctly state that rosacea should be regarded as an umbrella term, as several pathogenic and clinical subtypes exist. However, they also note that we examined the risk in patients with ocular rosacea, but not in other rosacea subtypes. We kindly direct their attention to the sensitivity analyses section of our article,1 in which we also described the risk for Parkinson disease (PD) in 751 patients with phymatous rosacea. This rosacea subtype had a fully adjusted incidence rate ratio of 1.43 (95% CI, 0.54-3.83; P = .50) associated with PD, and the incidence rate ratio for treatment with anti-Parkinson dopaminergic agents was 2.05 (95% CI, 1.21-3.45; P = .007). We encourage other groups with large data sets to replicate the association between rosacea and PD and, if possible, to further examine whether the association is restricted to certain subtypes.

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