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To the Editor We read with interest the study from Yokoyama et al.1 In this study, Yokoyama et al1 investigated the genetic overlap between Alzheimer disease and immune-mediated diseases including Crohn disease, ulcerative colitis, rheumatoid arthritis, type 1 diabetes, celiac disease, and psoriasis using 7 genome-wide association study summary data sets. They reported 8 single-nucleotide polymorphisms associated with both Alzheimer disease and immune-mediated diseases, especially rs2516049 (HLA-DRB5) and rs12570088 (IPMK).1 Using a gene expression data set, they further identified significantly altered expression of HLA-DRA and IPMK in Alzheimer disease brains compared with control brains.1
Jiang Q, Hu Y, Liu G. Association of Alzheimer Disease Susceptibility Variants and Gene Expression in the Human Brain. JAMA Neurol. 2016;73(10):1255. doi:10.1001/jamaneurol.2016.2796