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Comment & Response
October 2016

Association of Alzheimer Disease Susceptibility Variants and Gene Expression in the Human Brain

Author Affiliations
  • 1School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
JAMA Neurol. 2016;73(10):1255. doi:10.1001/jamaneurol.2016.2796

To the Editor We read with interest the study from Yokoyama et al.1 In this study, Yokoyama et al1 investigated the genetic overlap between Alzheimer disease and immune-mediated diseases including Crohn disease, ulcerative colitis, rheumatoid arthritis, type 1 diabetes, celiac disease, and psoriasis using 7 genome-wide association study summary data sets. They reported 8 single-nucleotide polymorphisms associated with both Alzheimer disease and immune-mediated diseases, especially rs2516049 (HLA-DRB5) and rs12570088 (IPMK).1 Using a gene expression data set, they further identified significantly altered expression of HLA-DRA and IPMK in Alzheimer disease brains compared with control brains.1

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