In Reply We thank Charidimou for reading our recently published article1 in JAMA Neurology on the risk for symptomatic intracerebral hemorrhage after intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) and high cerebral microbleed (CMB) burden on pre-IVT magnetic resonance imaging (MRI) screening,1 and for his timely discussion on the topic.
Tsivgoulis G, Katsanos AH, Alexandrov AV. The Dark Matter of Cerebral Microbleeds—Reply. JAMA Neurol. 2016;73(10):1256-1257. doi:10.1001/jamaneurol.2016.2937