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Comment & Response
October 2016

Factors Associated With Neurological Outcome After Childhood Stroke—Reply

Author Affiliations
  • 1Department of Pediatrics, University of Washington, Seattle
  • 2Division of Pediatric Neurology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee
JAMA Neurol. 2016;73(10):1257-1258. doi:10.1001/jamaneurol.2016.2934

In Reply We thank Goh and Sivakumaran for their interest in and comments on our article,1 which was a retrospective study of blood pressure, blood glucose, and fever and their associations with outcome after arterial ischemic stroke (AIS) in children. Although we did not find a significant association between hypertension and neurological outcome or death at 3 months after stroke, we found that when carefully tracked, vital sign abnormalities were very common in the poststroke period. In our future directions section,1 we proposed a larger prospective study precisely because of the limitations of our study design and conflicting results with a prior study that found that hypertension was associated with increased mortality but not poor neurological outcome at 1 year after stroke in children.2

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