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In Reply We thank Büchel and colleagues for their letter, and we are pleased to see that their considerations are based on a viewpoint almost entirely in agreement with our own. Their statement that pain matrix responses generated using traditional analysis methods and experimental designs are “confounded by unspecific effects” is a concise summary of our letter1 and a theme of much of our previous work.2
Salomons TV. Comparing Painful Stimulation vs Rest in Studies of Pain—Reply. JAMA Neurol. 2016;73(10):1259-1260. doi:10.1001/jamaneurol.2016.2992