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September 12, 2016

Encephalomyelitis Associated With Dengue Fever

Author Affiliations
  • 1Multiple Sclerosis Reference Center, Department of Neurology, Universidade Metropolitana de Santos, São Paulo, Brazil

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Neurol. Published online September 12, 2016. doi:10.1001/jamaneurol.2016.1416

A man in his 20s was referred to our multiple sclerosis reference center with a clinical demyelination syndrome. The patient was otherwise healthy until 2 weeks earlier, when he was diagnosed with dengue fever. For 5 days, the patient had a high temperature and a skin rash. The results of blood testing showed thrombocytopenia (70 × 103/μL platelets [to convert to × 109/L, multiply by 1]) and were IgM-positive for dengue fever. The patient started to recover from this viral infection, but 10 days later, he developed diplopia, optic neuritis, paraparesis, paresthesia, hyperreflexia in his lower limbs, abnormal proprioception, urinary incontinence, vertigo, and gait ataxia. The patient became bedridden and mentally confused and began sleeping excessively.

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