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Research Letter
November 2016

Chronic Subthreshold Cortical Stimulation to Treat Focal Epilepsy

Author Affiliations
  • 1Department of Neurology, Mayo Clinic, Rochester, Minnesota
  • 2Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota
JAMA Neurol. 2016;73(11):1370-1372. doi:10.1001/jamaneurol.2016.2857

Approximately 1 to 3 in 1000 people have drug-resistant focal epilepsy.1 Resective surgical procedures are the most effective treatments for patients with epilepsy but are not feasible when seizures originate from critical cortical areas, ie, the eloquent cortex. Despite evidence for efficacy, current approaches to focal brain stimulation rarely yield seizure-free outcomes.2 We report on 13 patients treated with continuous subthreshold electrical cortical stimulation, which led to the suppression of interictal epileptiform discharges (IEDs) and improvement in clinical seizures (ie, reduced frequency, with some experiencing reduced intensity and duration).

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