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To the Editor We agree with Reams and colleagues’ review1 finding that because mislocalized phosphorylated tau is neither pathognomic nor causative for clinical neurodegenerative disease, efforts focusing on identification of chronic traumatic encephalopathy in living people are not clinically useful. Chronic traumatic encephalopathy is present in equal incidence in normal healthy elderly individuals as in people with neurodegenerative disease.2 It is a pathologic finding with no clinical correlate.3,4
Samadani U, Hubbard M. Diagnosing Traumatic Encephalopathy Syndrome. JAMA Neurol. Published online September 19, 2016. doi:10.1001/jamaneurol.2016.2802