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Clinical Pathologic Conference
January 2017

A 63-Year-Old Man With Progressive Visual Symptoms

Author Affiliations
  • 1Sunnybrook Health Sciences Centre, Department of Neurology, University of Toronto, Toronto, Ontario, Canada
  • 2Center for Human Genetic Research, Massachusetts General Hospital/Harvard Medical School, Boston
  • 3Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston
  • 4Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston
  • 5Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston
JAMA Neurol. 2017;74(1):114-118. doi:10.1001/jamaneurol.2016.2210
Abstract

A 63-year-old man presented with a 4-year history of insidious onset and gradual progression of visual symptoms including right homonymous hemianopsia, alexia, and simultanagnosia with preserved memory. Magnetic resonance imaging, perfusion single-photon emission computed tomography, and fluorodeoxyglucose positron emission tomographic scans revealed strikingly asymmetric left parieto-occipital abnormality. Neuropsychological testing was performed. The differential diagnosis, pathologic findings, genetic testing results, and diagnosis are discussed.

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