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Research Letter
January 2017

Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-ε4 Carriers

Author Affiliations
  • 1The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia
  • 2IBM Research–Australia, Melbourne, Australia
  • 3Cooperative Research Center for Mental Health, Melbourne, Australia
JAMA Neurol. 2017;74(1):122-125. doi:10.1001/jamaneurol.2016.4406

The ε4 allele of APOE confers the greatest genetic risk for Alzheimer disease (AD), and recent data implicate brain-iron load as a pathogenic mechanism because ε4 carriage elevates the level of cerebrospinal fluid (CSF) ferritin.1 Controlled for potential confounders like inflammation and bleeding, CSF ferritin level, although not elevated in AD, was associated with longitudinal cognitive performance and the risk of developing AD.1 Herein, we investigate whether CSF ferritin level combines with established AD risk variables in predicting cognitive decline over 7 years in the preclinical phase.

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