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Editorial
January 3, 2017

Risk of Multiple Sclerosis After a Clinically Isolated SyndromeFrom Magnetic Resonance Imaging to Oligoclonal Bands to Activated T Cells

Author Affiliations
  • 1Multiple Sclerosis Center, Department of Neurology, University of California, San Francisco
JAMA Neurol. Published online January 3, 2017. doi:10.1001/jamaneurol.2016.5143

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by inflammation, demyelination, and neurodegeneration.13 The disease is chronic and its reach multifocal. Modern MS diagnosis accordingly rests on the paired tenets of dissemination in time (to distinguish MS from one-time inflammatory events) and dissemination in space (to distinguish MS from syndromes exclusively involving a single neuroanatomic localization).4

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