To the Editor We read with great interest the recently published article by Morotti and colleagues1 in JAMA Neurology as well as the accompanying Editorial by Alberts et al.2 The study corroborates and extends previous evidence on this topic3 by demonstrating that a lower calcium level is associated with a larger initial baseline hematoma volume and a higher risk of hematoma expansion in patients with intracerebral hemorrhage, and they also provide insights into the possible mechanisms for this association. While we appreciate that the limitations of the current study are clearly acknowledged in the article, some aspects might deserve further consideration.
Chen W, Wang L, Chen J. Considering Blood Pressure Level in the Association Between Serum Calcium Level and the Size and Expansion in Patients With Intracerebral Hemorrhage. JAMA Neurol. 2017;74(4):483. doi:10.1001/jamaneurol.2016.6045