Although vasopressor agents are frequently employed for the correction of hypotension, the effects of their administration on cerebral hemodynamics and metabolism in this circulatory disorder have not been adequately studied. Since the brain is one of the organs most vulnerable to reduction in oxygen delivery, such studies gain added significance. In a previous communication, Moyer et al.1 described the cerebral hemodynamic responses resulting from the continuous infusion of metaraminol (Aramine) and norepinephrine; with a rise in pressure from normotensive to hypertensive levels, the rate of cerebral blood flow decreased. In subjects with hypotension induced by ganglionic blocking agents, the administration of pressor agents was associated with an increase of cerebral blood flow to normal values. In this report, the effect of intravenously administered norepinephrine on cerebral hemodynamics and oxygen consumption in patients with hypotension resulting from or associated with a variety of clinical disorders is presented.
FAZEKAS JF, THOMAS A, JOHNSON JVV, YOUNG WK. Effect of Norepinephrine on Cerebral Hemodynamics in Severe Hypotension. AMA Arch Neurol. 1960;2(3):305–308. doi:10.1001/archneur.1960.03840090069008