This investigation was undertaken to determine whether characteristic changes occur in the serum proteins, glycoproteins, and lipoproteins in various neurologic diseases. We hoped to gain information on the pathogenesis of the particular disease under consideration and on the response of the body to it. Furthermore, we hoped such information might be helpful in differential diagnosis.
Many non-neurologic diseases cause changes in serum proteins,1 glycoproteins,2 and lipoproteins3; diseases arising outside the nervous system were excluded from this study.
A number of investigators have reported on changes in serum proteins accompanying multiple sclerosis4-7; others have studied blood lipids and lipoproteins with particular reference to multiple sclerosis.8-10 Roboz and co-workers11 recently contributed findings regarding changes in serum polysaccharides in patients with brain tumor.
In this report we are presenting observations on the serum proteins, glycoproteins, and lipoproteins in 135 cases that represent a number of commonly
HILL NC, GOLDSTEIN NP, McKENZIE BF, McGUCKIN WF, SVIEN HJ. Serum Proteins, Glycoproteins, and Lipoproteins in Neurologic Diseases. AMA Arch Neurol. 1960;2(3):341–347. doi:10.1001/archneur.1960.03840090105013