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June 1962

Late-Life Myopathy Occurring with Sjögren's Syndrome

Author Affiliations

From the Branch of Medical Neurology, National Institutes of Neurological Diseases and Blindness, National Institutes of Health.

Arch Neurol. 1962;6(6):428-438. doi:10.1001/archneur.1962.00450240006002

Introduction  Myopathies commencing during the adult years have been shown to be associated with several groups of generalized diseases. For example, the relationship of late-life myopathy to malignancies, particularly those of the lung, is now well recognized.1,2 Similarly, myopathy has occurred frequently in combination with the so-called collagen diseases—rheumatoid arthritis, lupus erythematosis, scleroderma, and polyarteritis.3-8 A number of other conditions, many of them poorly understood systemic diseases such as sarcoidosis, have also been associated with myopathy.We have recently studied 4 cases of myopathy which were found to be associated with Sjögren's syndrome, a symptom complex including hypofunction of the lacrimal glands, diminished salivary secretion, and, often, rheumatoid arthritis. Aside from the present cases,* this association has not been remarked upon previously.It is the purpose of this article to report in detail the clinical and laboratory features of these cases, and to review briefly some of the

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