November 1962

Electrophysiological Alterations in AdrenalectomyChanges in Brain Stem Conduction, Excitability, and Sensitivity to Anesthesia in Adrenalectomized Cats

Author Affiliations

Department of Nervous Diseases (Laboratory of Experimental Neurology), Hadassah University Hospital and the Hebrew University-Hadassah Medical School.

Arch Neurol. 1962;7(5):460-470. doi:10.1001/archneur.1962.04210050096011

Since the classical observations made by Addison on disturbances occurring in patients suffering from adrenocortical insufficiency, various neurological and mental alterations have suggested that the vital hormones are essential for normal function of the central nervous system. The mental changes in these patients consist among others of irritability, unexplained bursts of anger, disturbed sleep with nightmares, depression, periods of amnesia and unreality, and occasionally hallucinations and paranoid psychosis.1-4 Some of the patients exhibit motor and sensory disturbances, changes in reflexes, pupillary and visual abnormalities, drowsiness, and confusion, which is occasionally accompanied by convulsions.1-3 Among other abnormalities described in hypoadrenalism are slowing of the EEG in patients1,2,5,6 and experimental animals7 and an increase in brain excitability of the latter,8,9 as determined by the threshold for electrically induced seizures.

Various metabolic derangements in the central nervous system have been described in hypoadrenalism,9 but there is very

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