Among the enzymes normally found in the body are the transaminases which catalyze the interconversion of an amino acid with a keto acid. The two most widely studied transaminases are glutamic oxaloacetic transminase and glutamic pyruvic transaminase, the former being the subject of the current study. Since skeletal muscle contains a high concentration of glutamic oxaloacetic transaminase, the present investigation, and extension of previous work with Fleisher, was carried out to ascertain whether the serum levels of this enzyme are altered in patients with muscular dystrophy.
Cohen studied these enzymes and, with Hekhuis, noted their wide distribution in the body. Another tissue enzyme, aldolase, was soon discovered by Warburg and Christian who found it to be elevated in the serum of rats with tumors. Sibley and Lehninger, in a survey of a large number of patients with various diseases, found that aldolase did not constitute a good test for cancer
SIEKERT RG. SGOT Level in Patients with Muscular Dystrophy. Arch Neurol. 1963;8(1):56–63. doi:10.1001/archneur.1963.00460010072008