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June 1963

Cerebral Peduncle in Propagation of ConvulsionsRole in Focal and Generalized Convulsions

Author Affiliations

From the Division of Neurological Surgery, The Johns Hopkins University, School of Medicine.

Arch Neurol. 1963;8(6):581-590. doi:10.1001/archneur.1963.00460060011001

Introduction  Focal and many generalized convulsions are considered to originate in the cerebral cortex. The pathways by which the cortical discharges are carried to the muscles which give rise to the contractions characteristic of a seizure have been imperfectly demonstrated. It, therefore, seemed advisable to investigate the motor pathways passing through the cerebral peduncle. The role of these efferent fibers to the pons, medulla oblongata, and spinal cord in the propagation of seizures has been studied previously with inconclusive results. In 1909, Economo and Karplus3 reported that cortical seizures could be induced after cerebral pedunculotomy in cats. Others have studied seizures induced after sectioning the pyramid in cats,7,9,13,15 dogs,4,5 and monkeys.5,7,9,15 Some have recorded discharges from the pyramidal tract during cortically induced seizures.1,10,17 A few have studied preparations in which only the pyramidal tract is intact.4,10,17 However, the functional significance of the tracts of

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