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Article
November 1964

EEG in Holoprosencephaly (Arhinencephaly)

Author Affiliations

INDIANAPOLIS; PHOENIX, ARIZ

Arch Neurol. 1964;11(5):507-520. doi:10.1001/archneur.1964.00460230057005
Abstract

The origins of EEG rhythms, the physiologic and pathophysiologic mechanisms, have never been fully defined. Nevertheless in the quest for certainty, clinicians search for EEG patterns which may be diagnostic of a brain lesion or disease. Our study of the EEG's of ten patients having uncleft prosencephalons disclosed some suggestively diagnostic patterns which may be unique but do simulate other disorders. The uncleft prosencephalons of our patients usually were small relative to the cranial volume, and they were surrounded by pools of cerebrospinal fluid. The prosencephalons had different orientations along the sagittal axis of the cranium. These anatomic factors, their relation to cerebral electrogenesis and to the propagation of electrical potentials, provide interesting problems in EEG-pathoanatomic correlation.

Specification of the Teratisms Studied  The generic terms cyclopia-arhinencephaly1 or holoprosencephaly2 designate a graded series of malformations beginning with cyclopia and merging with the normal face and brain.1-5 Pathognomonic median

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