THE MECHANISMS by which an organism regulates its intake have been the subject of numerous investigations for some time. Prior to this century three main theories were put forth to explain the origin of hunger.1 One conceived of hunger as a sensation of peripheral origin, usually felt to arise from the stomach. The second placed the emphasis on central phenomena, postulating the existence of a "hunger center" in the brain, and the third explained hunger as a sensation of general origin with all organs, including the brain, entering into its perception.
At the present time there is still no universally accepted theory which satisfactorily accounts for all the reported experimental data. It is generally accepted that the central nervous system (CNS) plays an important, if not definitive, role in the regulation of an organism's intake. A number of theories have been put forth to explain the manner
SKULTETY FM. Changes in Caloric Intake Following Brain Stem LesionsI. Preoperative Observations. Arch Neurol. 1966;14(4):428–437. doi:10.1001/archneur.1966.00470100084011