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May 1966

Experimental Epilepsy.

Arch Neurol. 1966;14(5):569. doi:10.1001/archneur.1966.00470110113017

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A well-organized review of a subject by an experienced neurophysiologist in the field is always welcome. Since the author discusses epilepsy from the viewpoint of a physiologist rather than a clinician, it is natural that he assumes an afterdischarge to be the prototype of an epileptic seizure. He presents a thorough review of the voluminous world literature on cortical and subcortical after-discharges induced electrically, chemically, or pharmacologically with illustrations from the author's and other authors' papers of the characteristics of the different phenomena.

Although the author considers the epileptic focus to represent the recruitment and synchronization of many epileptic neurons, he does not believe there is a relationship between the high frequency firing of the soma and the activity recorded by pial macroelectrodes. Propagation of the epileptic activity is both ephaptic and axonal and results in synchronous discharges of a great number of cortical and subcortical neurons. Yet, the author

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