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November 1966

Effects of Steroids on Cerebral Electrical ActivityEpileptogenic Effects of Conjugated Estrogens and Related Compounds in the Cat and Rabbit

Author Affiliations

From the Department of Neurology, New England Medical Center Hospitals, and Tufts University School of Medicine, Boston.

Arch Neurol. 1966;15(5):521-532. doi:10.1001/archneur.1966.00470170075008

RELATIONSHIPS, both general and specific, between ovarian function and seizure susceptibility have long been postulated. Analysis of patients who have the onset of a seizure disorder in the age range 10 to 20 years indicates a prevalence of females among patients subject to "petit mal"1 and to seizures of other forms.2 Significant age-related sex differences occur in the incidence of light-evoked electroencephalographic abnormalities with a higher incidence in the female during the years of active ovarian function.3

Seizures in many females are increased in their frequency in relation to the menstrual cycle. Logothetis et al4 postulated that a premenstrual exacerbation of seizures might be related to increased estrogenic activity. A lowering of electroshock threshold during estrus in the rat has been related to high levels of circulating estradiol during this phase.5 The exact relation of circulating estrogenic substances to seizure exacerbations in the human

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