HEREDITARY occurrence of various myopathies is well established.1-3 Duchenne, in the 1860's, observed a preponderance of affected males, 11 out of 13 cases,4 and the eponym "Duchenne muscular dystrophy" has come to epitomize a disease limited to young boys.4,5 However, familial cases, similar to this type of muscular dystrophy, have also been seen in girls,6-11 and some 40 cases12 are known.
The mode of inheritance of muscular dystrophy of later onset is not as clear. Although families with sex-linked inheritance are known,3,13,14 simple autosomal recessive inheritance usually prevails. There are also many sporadic cases.12,15
Though a slight preponderance of females has been reported16 in facioscapulohumeral dystrophy, exclusive involvement of females in one kindred has not been recorded. A family with limb-girdle dystrophy exhibiting precisely such a pattern of inheritance is here presented.
Report of Cases
The following Anglo-Saxon family, residing in
Henson TE, Muller J, DeMyer WE. Hereditary Myopathy Limited to Females. Arch Neurol. 1967;17(3):238–247. doi:10.1001/archneur.1967.00470270016003