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January 1968

Cerebral Metabolic and Circulatory Responses to Induced Convulsions in Animals

Author Affiliations

New York
From the Department of Neurology, Cornell University Medical College, New York.

Arch Neurol. 1968;18(1):1-13. doi:10.1001/archneur.1968.00470310015001

CONVULSIONS place a heavy metabolic demand upon the brain and are followed by metabolic and clinical sequelae which are incompletely understood. Although the blood pressure1,2 and cerebral blood flow3-6 are known to increase during seizures, efforts to quantify the increase in flow and to document the dynamics of the associated changes in cerebral metabolism have yielded fragmentary and sometimes conflicting results. Thus, some workers have reported that the oxygen tension of the cerebral tissue or venous blood falls during seizures,7,8 while others have noted a rise.9 Also, some workers have reported large increases in cerebral acid products during convulsions,6,10 while others have found no predictable elevation.5 Part of the explanation for these discrepancies may be that in many sets of observations the effects on the cerebral circulation of alterations in muscle metabolism and respiration were not always clearly differentiated from the direct metabolic

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