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Article
September 1968

Mononeuritis Multiplex in Lepromatous Leprosy

Author Affiliations

New York
From the Neurological Clinical Research Center, Department of Neurology, College of Physicians and Surgeons, and the Neurological Institute, Columbia-Presbyterian Medical Center, New York.

Arch Neurol. 1968;19(3):310-314. doi:10.1001/archneur.1968.00480030088009
Abstract

MONONEURITIS multiplex refers to involvement of several or many peripheral nerves at the same or different points in time by a disease process. It is usually asymmetric, particularly in early stages, and has been reported to occur in periarteritis nodosa,1 diabetes mellitus,2 and leprosy.3-7

Two main types of leprosy, lepromatous and tuberculoid, have been described.3,4 Low resistance in lepromatous leprosy is evidenced by a negative lepromin skin test and positive skin scrapings for acid-fast bacilli. Patients present with papular or nodular pigmented skin lesions together with slowly progressive symmetrical sensory polyneuropathy. Considerable resistance occurs in tuberculoid leprosy as indicated by a strongly positive lepromin skin test and negative skin scrapings for acid-fast bacilli. It begins with depigmented slightly erythematous skin lesions and a sudden severe asymmetric neuritis (mononeuritis multiplex). Borderline and indeterminate groups of leprosy have also been described.

Electromyographic (EMG)5-7 and time-intensity curve studies

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