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Article
July 1969

Clostridium perfringens MeningitisReport of a Case With Neuropathological Observations

Author Affiliations

Cleveland
From the departments of pathology (Dr. Conomy) and medicine (Dr. Dalton), Cleveland Metropolitan General Hospital and Case Western Reserve University, Cleveland.

Arch Neurol. 1969;21(1):44-50. doi:10.1001/archneur.1969.00480130058006
Abstract

BACTERIAL meningitis due to Clostridium perfringens is rare. Cases published previously have been associated with penetrating craniocerebral trauma,1-10 and many have been associated with clostridial cerebral abscesses.1,5,7-9 In the recorded war experiences of the Russian and British medical military staffs during World War II, C perfringens was only rarely isolated from the cerebrospinal fluid (CSF) of patients with serious and undoubtedly contaminated head injuries.7-9 In keeping with the small number of cases published in which autopsy study was made,1,4,6 the neuropathologic changes accompanying this disease have received little attention. This report concerns a patient who contracted C perfringens meningitis while hospitalized, in whom the diagnosis was established during life, and who succumbed rapidly to a particularly vicious nervous system infection. In contrast to all other patients reported with this unusual meningitic illness, he did not have precedent penetrating craniocerebral trauma.

Report of a Case  An

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