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June 1970

Experimental Brain EdemaThe Role of a Factor in Brain Supernatant in the Prevention of Edema

Author Affiliations

Chicago; Tokyo
From the Division of Neurological Surgery, University of Chicago Hospitals, Chicago, and the Department of Neurosurgery, Juntendo University School of Medicine, Tokyo (Dr. Ishii).

Arch Neurol. 1970;22(6):521-527. doi:10.1001/archneur.1970.00480240041007

IT HAS BEEN suggested in a previous paper1 that the biological function of the mitochondria in brain tissue decreases in association with the initiation and the development of brain edema. The mechanism of the impairment in mitochondrial function has been partially elucidated by many workers in the general biochemical field. It has also been found that the long-chain, free, fatty acids present in various tissues under physiological conditions can serve as a strong uncoupler in oxidative phosphorylation. Some investigators, on the other hand, have claimed that decay of mitochondrial function occurs independently, with an accumulation of free fatty acids.

We, therefore, undertook a more detailed study of this phenomenon in the hope of gaining information concerning the cause and the mechanism of swelling of brain tissue.

Tightly coupled mitochondria were isolated from fresh rat brain and were aged in vitro at 30 C in order to simplify the

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