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Article
January 1971

Familial Hypoplasia of Both Internal Carotid Arteries

Author Affiliations

Denver
From the Division of Neurology (Dr. Austin) and the Department of Radiology (Dr. Stears), University of Colorado Medical Center, Denver.

Arch Neurol. 1971;24(1):1-10. doi:10.1001/archneur.1971.00480310029001
Abstract

HYPOPLASIA of the internal carotid artery may present clinically with an episode either of cerebral ischemia or of cerebral hemorrhage. Only sporadic cases have been reported thus far; the familial incidence of this syndrome has not been demonstrated in Caucasians.1-3

The primary purpose of the present report is to document the familial occurrence of hypoplasia of both carotid arteries in two and possibly three brothers. Their initial symptoms occurred at 18, 30, and 33 years of age. A secondary purpose is to review the literature and to focus on those aspects of this disorder which are still puzzling.

There are two implications of this study. The first is that a family history of cerebral ischemia or of hemorrhage in siblings should lead one to include hypoplasia of the internal carotid artery in the differential diagnosis. The second implication is that some of the disease mechanisms causing the hypoplasia

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