A patient with probable systemic lupus erythematosus (SLE) was found at necropsy to have a benign brain tumor classified as an atypical vascular hamartoma. Electron microscopic study revealed myxovirus-like particles in the tumor nuclei. It is concluded that the SLE and its corticosteroid treatment caused an immunologic deficit which facilitated virus invasion of a preexisting hamartoma. This case exemplifies the possibility in a wide range of diseases that the detection of a virus may merely indicate secondary invasion of previously damaged tissue.
Norris FH, Aguilar MJ, Harman CE. Virus-like Particles in a Case of Vasculitis With Brain Tumor. Arch Neurol. 1972;26(3):212–217. doi:10.1001/archneur.1972.00490090038002