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March 1972

Virus-like Particles in a Case of Vasculitis With Brain Tumor

Author Affiliations

San Francisco
From the School of Medical Sciences, University of the Pacific, and the Institute of Medical Sciences, Pacific Medical Center, San Francisco.

Arch Neurol. 1972;26(3):212-217. doi:10.1001/archneur.1972.00490090038002

A patient with probable systemic lupus erythematosus (SLE) was found at necropsy to have a benign brain tumor classified as an atypical vascular hamartoma. Electron microscopic study revealed myxovirus-like particles in the tumor nuclei. It is concluded that the SLE and its corticosteroid treatment caused an immunologic deficit which facilitated virus invasion of a preexisting hamartoma. This case exemplifies the possibility in a wide range of diseases that the detection of a virus may merely indicate secondary invasion of previously damaged tissue.