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August 1972

Cell-Mediated Hypersensitivity to Neural AntigensOccurrence in Human Patients and Nonhuman Primates With Neurological Diseases

Author Affiliations

Boston; Bethesda, Md
From the Department of Neurology, Boston University School of Medicine (Drs. P. Behan, W. Behan, and Feldman); Boston Veterans Administration Hospital (Drs. P. Behan and Feldman); Brockton Veterans Administration Hospital (Dr. W. Behan), Boston; and the Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Md (Dr. Kies).

Arch Neurol. 1972;27(2):145-152. doi:10.1001/archneur.1972.00490140049008

The method of macrophage migration inhibition was used to study cell-mediated hypersensitivity to neural antigens in patients with multiple sclerosis. Patients with other neurologic diseases and nonhuman primates sensitized with neural antigens were also included in the study. Cellmediated hypersensitivity to peripheral nerve antigens was demonstrated in patients with Landry-Guillain-Barré-Strohl polyneuritis, but no sensitivity to central or peripheral nerve antigens was found in patients with multiple sclerosis (or other neurological disease) regardless of the stage of the disease. In spite of their failure to react to neural antigens, cells from patients sensitive to streptokinase-streptodornase antigens produced macrophage inhibition factor in the presence of streptokinase-streptodornase. Cells from all experimental animals were sensitive to purified protein derivative and reacted positively to those neural antigens with which they had been sensitized.