The fundamental studies of Spielmeyer1 led to the identification of various types of neuronal changes and the subsequent stand-ardization and development of neuropathologic research. From the vast material examined, Spielmeyer and his colleagues formulated a concept of a vascular origin for many of the cerebral lesions and, over the years, only slight modifications to the original concept have been advanced. I shall here merely mention that while most investigators have agreed that the "ischemic neuronal disease" of Spielmeyer represents an irreversible pathologic process, Camerer2 pointed out the similarity of such changes to a postmortem autolytic process, and Lindenberg3 advocated the combination of an intravital and a postmortem cell reaction.
In systematic studies of human neuropathologic material from a general hospital, lesions attributable to circulatory disturbances are commonly found. Further analysis of such material will often indicate that the cerebral blood flow has been impaired
Cammermeyer J. "Ischemic Neuronal Disease" of SpielmeyerA Reevaluation. Arch Neurol. 1973;29(6):391–393. doi:10.1001/archneur.1973.00490300053006