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April 1974

Brain Permeability of Water

Author Affiliations

St. Louis
From the Division of Radiation Sciences (Drs. Raichle and Eichling), Mallinckrodt Institute of Radiology; Department of Neurology (Dr. Raichle) and Division of Neurosurgery (Dr. Grubb), Washington University School of Medicine, St. Louis.

Arch Neurol. 1974;30(4):319-321. doi:10.1001/archneur.1974.00490340047010

The equilibration of labeled water (H215O) with the exchangeable water pool of brain was examined during a single capillary transit. The labeled water did not equilibrate freely when cerebral blood flow (CBF) exceeded 20 (ml/100 gm)/min in the rhesus monkey. At normal CBF [.. 50 (ml/100 gm)/min] only 90% of the injected bolus freely equilibrated with brain. This value progressively declined as CBF increased.