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April 1974

Inosiplex and Amyotrophic Lateral SclerosisTherapeutic Trial in Patients on Guam

Author Affiliations

Bethesda, Md; Agana, Guam; Wakayama, Japan; Tamuning, Guam; Chapel Hill, NC
From the Epidemiology Branch, C&FR, National Institute of Neurological Diseases and Stroke, Bethesda, Md (Dr. Brody); Guam Memorial Hospital, Agana, Guam (Dr. Chen); Division of Neurological Diseases, Wakayama Medical College, Wakayama, Japan (Dr. Yase); NINDS

Arch Neurol. 1974;30(4):322-323. doi:10.1001/archneur.1974.00490340050011

We report negative results in a doubleblind study of the therapeutic value of inosiplex in Guamanian patients with amyotrophic lateral sclerosis. Similar rates of progression and mortality over a two-year period were observed in eight inosiplex-treated patients and eight matched controls who received a placebo, and an additional five patients who received inosiplex but for whom no controls were available. Most patients, whether given placebo or drug, experienced subjective improvement, and some gained weight during the early phase of the study. Regardless of treatment, approximately 25% of the patients did not progress clinically during the two years of observation.