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May 1976

Pathogenesis of Muscular Dystrophies

Author Affiliations

From the H. Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Diseases, the College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York.

Arch Neurol. 1976;33(5):315-321. doi:10.1001/archneur.1976.00500050001001

• Three major theories have been proposed to explain the pathogenesis of muscular dystrophies: abnormal microvascular supply of muscle, abnormal neuronal influence on muscle, or a genetic fault of the surface membrane. The cumulative evidence suggests that an abnormal muscle surface membrane is the most likely, but this has not been proven.