• Three major theories have been proposed to explain the pathogenesis of muscular dystrophies: abnormal microvascular supply of muscle, abnormal neuronal influence on muscle, or a genetic fault of the surface membrane. The cumulative evidence suggests that an abnormal muscle surface membrane is the most likely, but this has not been proven.
Rowland LP. Pathogenesis of Muscular Dystrophies. Arch Neurol. 1976;33(5):315–321. doi:10.1001/archneur.1976.00500050001001