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August 1976

Giant Axonal Swelling in "Huffer's" Neuropathy

Author Affiliations

From the departments of neurology (Dr Oh) and pathology (Dr Kim), University of Alabama School of Medicine, and the Veterans Administration Hospital, Birmingham.

Arch Neurol. 1976;33(8):583-586. doi:10.1001/archneur.1976.00500080061010

• A young man with a long history of "huffing" of lacquer thinner developed toxic peripheral neuropathy. Clinical improvement occurred several weeks after cessation of exposure. Substantial slowing in nerve conduction was noted. Sural nerve biopsy specimen showed (1) giant axonal swelling, (2) axonal degeneration, and (3) an increased paranodal gap. We believe that "huffer's" neuropathy is a primary axonal neuropathy with secondary demyelination.