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December 1977

The Invasive Pituitary AdenomaA Prolactin-Producing Tumor

Author Affiliations

From the Departments of Neurology (Dr Lundberg), Oto-Rhino-Laryngology (Dr Drettner), Diagnostic Roentgenology (Dr Hemmingsson), Clinical Cytology (Dr Stenkvist), and Clinical Chemistry (Dr Wide), University Hospital, Uppsala, Sweden.

Arch Neurol. 1977;34(12):742-749. doi:10.1001/archneur.1977.00500240030005

• Invasive pituitary adenoma was diagnosed by means of a transnasal aspiration biopsy method in 11 patients with extensive destruction of bone in the sellar region. In most cases the initial symptoms were decrease of libido and potency or amenorrhea-galactorrhea. Later, chiasmatic compression developed in six patients, ocular motor signs in two, and epilepsy in two. Most of the patients had symptoms for many years; in two, the tumor was discovered by chance. They all had very high serum-prolactin values. The patients were treated with irradiation, and the prognosis seems to be relatively favorable.