• Invasive pituitary adenoma was diagnosed by means of a transnasal aspiration biopsy method in 11 patients with extensive destruction of bone in the sellar region. In most cases the initial symptoms were decrease of libido and potency or amenorrhea-galactorrhea. Later, chiasmatic compression developed in six patients, ocular motor signs in two, and epilepsy in two. Most of the patients had symptoms for many years; in two, the tumor was discovered by chance. They all had very high serum-prolactin values. The patients were treated with irradiation, and the prognosis seems to be relatively favorable.
Lundberg PO, Drettner B, Hemmingsson A, Stenkvist B, Wide L. The Invasive Pituitary AdenomaA Prolactin-Producing Tumor. Arch Neurol. 1977;34(12):742-749. doi:10.1001/archneur.1977.00500240030005