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July 1978

Polyneuropathy in Waldenström's MacroglobulinemiaDeposition of M Component on Myelin Sheaths

Author Affiliations

From the Department of Neurology, Hôpital du Haut-Lévêque (Drs Julien, Vallat, Lagueny, and Darriet), and the Jean Abadie Neuropathology Center (Drs Vital and Deminiere), Bordeaux, France.

Arch Neurol. 1978;35(7):423-425. doi:10.1001/archneur.1978.00500310025005

• A chronic sensory neuropathy was the initial symptom in a case of Waldenström's macroglobulinemia in a 53-year-old woman.

Ultrastructural analysis of a biopsied peripheral nerve revealed a modification of the lamellar structure of the myelin sheath. Immunofluorescent microscopy showed IgM-positive deposits on the myelin sheath. The monoclonal globulin (M component) present in the myelin appears to be a causative factor in the neuropathy.