• A chronic sensory neuropathy was the initial symptom in a case of Waldenström's macroglobulinemia in a 53-year-old woman.
Ultrastructural analysis of a biopsied peripheral nerve revealed a modification of the lamellar structure of the myelin sheath. Immunofluorescent microscopy showed IgM-positive deposits on the myelin sheath. The monoclonal globulin (M component) present in the myelin appears to be a causative factor in the neuropathy.
Julien J, Vital C, Jean-Michel Vallat , Lagueny A, Deminiere C, Darriet D. Polyneuropathy in Waldenström's MacroglobulinemiaDeposition of M Component on Myelin Sheaths. Arch Neurol. 1978;35(7):423–425. doi:10.1001/archneur.1978.00500310025005