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August 1979

Continuous Muscle Fiber ActivityA Case With Unusual Clinical Features

Author Affiliations

From the Departments of Neurology (Dr Barron) and Pathology (Dr Heffner), School of Medicine, State University of New York at Buffalo, and the Millard Fillmore Hospital, Buffalo, NY (Drs Barron and Heffner).

Arch Neurol. 1979;36(8):520-521. doi:10.1001/archneur.1979.00500440090022

• A patient with continuous muscle fiber activity is described. From our search of the literature, we believe this is the oldest patient with a reported case of this disorder, and the symptoms and treatment varied from previously reported cases in these respects: symptoms remained confined to the lower extremities after 18 months had elapsed, there was no response to phenytoin sodium or carbamazepine, and the patient required a full dose of tubocurarine chloride to stop the abnormal myoelectric potentials. A site of dysfunction in the unbranched motor axon is suggested as the locus of generation of the stimulus for the abnormal myoelectric activity.