• A trial of the antispastic drug baclofen was made in amyotrophic lateral sclerosis. Some patients noted reduction of tonus and spasticity; but others had no benefit, nor was the course of the disease altered by long-term administration of baclofen. No major side effects occurred.
Norris FH, Sang U K, Sachais B, Carey M. Trial of Baclofen in Amyotrophic Lateral Sclerosis. Arch Neurol. 1979;36(11):715–716. doi:10.1001/archneur.1979.00500470085019