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May 1980

Amyotrophic Lateral Sclerosis With Antecedent Poliomyelitis

Author Affiliations

From the Departments of Neurology (Drs Roos and Antel) and Neuropathology (Dr Wollmann), University of Chicago, Division of Biological Sciences, Pritzker School of Medicine, Chicago, and the Division of Oncology, Department of Medicine (Dr Viola), University of Connecticut Health Center, Framington, Conn, and the Center for Disease Control (Dr Hatch), Atlanta.

Arch Neurol. 1980;37(5):312-313. doi:10.1001/archneur.1980.00500540090016

• Histopathological and virological studies were performed on autopsy tissue from a 47-year-old man who had a history of acute poliomyelitis at age 15 years and died after a three-year course of amyotrophic lateral sclerosis (ALS). The poliovirus serologic tests suggested prior infection with poliovirus type 3 but no ongoing poliovirus infection. The CNS showed typical features of ALS with no inclusion bodies or inflammatory cells. Attempts to isolate poliovirus in the CNS were unsuccessful and results of immunofluorescence studies for poliovirus antigen were negative. Molecular hybridization experiments using a DNA copy of the complete poliovirus genome failed to demonstrate poliovirus-related RNA or DNA sequences in the CNS. These studies, using sensitive techniques, indicate that there was no evidence of the continuing presence of poliovirus in this patient with ALS and antecedent poliomyelitis.