• Schwann cells cultures were established from 40 human peripheral nerves that underwent biopsy according to an explant-reexplantation technique that markedly reduces non-Schwann cells and achieves cultures greatly enriched in Schwann cells suitable for a wide range of studies. Described are the growth characteristics and histochemical, ultrastructural, and ultrastructural-cytochemical patterns of normal human cultured Schwann cells from 12 patients with dysneuronal neuropathies or with no demonstrable peripheral nerve abnormality. These findings serve as a basis of comparison when seeking abnormalities of Schwann cells grown from peripheral nerves of patients with putative dysschwannian neuropathies.
Askanas V, Engel WK, Dalakas MC, Lawrence JV, Carter LS. Human Schwann Cells in Tissue Culture Histochemical and Ultrastructural Studies. Arch Neurol. 1980;37(6):329–337. doi:10.1001/archneur.1980.00500550031001