July 1980

Spinal Myoclonus With Vacuolar Degeneration of Anterior Horn Cells

Author Affiliations

From the Division of Neurology, Department of Neurological Science and Surgery and Neurology, Henry Ford Hospital, Detroit. Dr Shivapour is now with the Department of Neurology, University of Iowa College of Medicine, Iowa City.

Arch Neurol. 1980;37(7):451-453. doi:10.1001/archneur.1980.00500560081014

• Myoclonic contractions of muscles in the abdominal wall and lower extremities developed in a 47-year-old paraplegic woman. The spinal cord was compressed from T-3 to T-8 by an extradural renal cell carcinoma metastasis. To our knowledge, previous studies of patients with spinal myoclonus have not reported a pathologic correlation. In our patient, a focal morphologic change that consisted of vacuolar degeneration and chromatolysis of anterior horn cells was found at the levels of the spinal cord corresponding to the involved muscles. The myoclonus may be spinal in origin and due to an increased excitability of anterior horn cells during the period of sublethal injury.