• A 12-year-old, previously healthy boy was seen with typical signs of acute disseminated encephalomyelitis four days after influenza vaccination. Computerized tomography demonstrated an extensive subcortical low-density area in the left cerebral hemisphere. The CSF contained elevated levels of immunoglobulins, especially IgG, and an abnormal k:λ chain ratio. Skin tests for hypersensitivity to egg protein were negative, but reaugmentation of CSF protein and immunoglobulin levels was observed within ten days after skin tests.
Saito H, Endo M, Takase S, Itahara K. Acute Disseminated Encephalomyelitis After Influenza Vaccination. Arch Neurol. 1980;37(9):564-566. doi:10.1001/archneur.1980.00500580060009