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September 1980

Acute Disseminated Encephalomyelitis After Influenza Vaccination

Author Affiliations

From the Division of Clinical Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan.

Arch Neurol. 1980;37(9):564-566. doi:10.1001/archneur.1980.00500580060009

• A 12-year-old, previously healthy boy was seen with typical signs of acute disseminated encephalomyelitis four days after influenza vaccination. Computerized tomography demonstrated an extensive subcortical low-density area in the left cerebral hemisphere. The CSF contained elevated levels of immunoglobulins, especially IgG, and an abnormal k:λ chain ratio. Skin tests for hypersensitivity to egg protein were negative, but reaugmentation of CSF protein and immunoglobulin levels was observed within ten days after skin tests.