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Article
March 1981

Collagen Localization in Normal and Fibrotic Human Skeletal Muscle

Author Affiliations

From the Medical Neurology Branch (Drs M. Foidart and Engel) and the Laboratory of Developmental Biology and Anomalies (Dr J.-M. Foidart), National Institutes of Health, Bethesda, Md.

Arch Neurol. 1981;38(3):152-157. doi:10.1001/archneur.1981.00510030046006
Abstract

• The distribution of types I to IV collagen, types I and III p-N collagen, and fibronectin in human skeletal muscle was studied by immunofluorescence using purified antibodies to those proteins. In normal muscle, types I and III collagen, types I and III p-N collagen, and fibronectin were localized in the endomysium and perimysium. Type IV collagen was restricted to basement membrane. Type II collagen was not present. In Duchenne's muscular dystrophy and dermatomyositis/polymyositis (DM/PM), the prominently increased endomysial and perimysial fibrosis consisted of types I and III collagen, types I and III p-N collagen, and fibronectin. In DM/PM, thickening of the walls of perimysial venular and arteriolar vessels was associated with accumulation of types I and III collagen, types I and III p-N collagen, and fibronectin, as well as type IV collagen. There was no disease-specific accumulation of collagen, p-N collagen, or fibronectin.

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