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Article
June 1984

γ-Aminobutyric Acid and Homovanillic Acid Concentration in the CSF of Patients With Senile Dementia of Alzheimer's Type

Author Affiliations

From the Psychiatric Hospital of the Technical University of Munich (Dr Zimmer, Mr Weihmayr, and Dr Lauter); the Department of Biochemistry of the Neurological Hospital of the University of Groningen, the Netherlands (Dr Teelken and Mr Trieling); and the Institute of Anesthesiology of the University of Munich (Dr Weber).

Arch Neurol. 1984;41(6):602-604. doi:10.1001/archneur.1984.04210080010005
Abstract

• The investigation of enzyme and neurotransmitter levels and/or their metabolites in the CSF of patients with senile dementia of Alzheimer's type (SDAT) could become a promising approach for a clinical research and diagnostic procedure. To learn more about the metabolic reflections of central metabolism in the CSF of patients with SDAT, we measured CSF levels of γ-aminobutyric acid (GABA) and homovanillic acid (HVA), the dopamine metabolite. In 16 female patients with SDAT and in eight matched control patients, CSF GABA levels were measured by ion exchange with fluorimetric detection, and HVA levels were measured fluorimetrically. The GABA content of the CSF was significantly reduced in patients with SDAT, whereas the HVA level was unchanged.

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