• The analysis of the results of many well-designed, double-blind trials of anticonvulsant drugs has been unsophisticated. We draw attention to the nonrandom occurrence of seizures, which negates the simple comparison of average seizure frequency. We propose a method of taking into account clustering of seizures when deciding on the appropriate length of follow-up after introducing a new treatment. Deterministic and nondeterministic models were used to show why there may be reasons for sometimes using more than one drug in the treatment of epilepsy.
Hopkins A, Davies P, Dobson C. Mathematical Models of Patterns of SeizuresTheir Use in the Evaluation of Drugs. Arch Neurol. 1985;42(5):463–467. doi:10.1001/archneur.1985.04060050061009