• We have evaluated the sensitivity of the most recent and most frequently used criteria for the diagnosis of definite multiple sclerosis by the retrospective study of the clinical files of 70 pathologically confirmed cases. For each case, the date of diagnosis was determined separately using different sets of criteria. The delay of diagnosis was then calculated. The diagnosis was made significantly earlier when certain criteria were used. This was more marked in the earlier years of the disease. We also found that cases of multiple sclerosis with progressive courses were diagnosed later than cases with other courses, whatever the criteria used. This was statistically significant only for a single criterion.
Izquierdo G, Hauw J, Lyon-Caen O, Marteau R, Escourolle R, Buge A, Castaigne P, Lhermitte F. Value of Multiple Sclerosis Diagnostic Criteria70 Autopsy-Confirmed Cases. Arch Neurol. 1985;42(9):848–850. doi:10.1001/archneur.1985.04060080026010