April 1987

Mood Disorder and Multiple Sclerosis

Author Affiliations

From the Departments of Psychiatry (Drs Joffe and Lippert and Ms Horvath) and Neurology (Drs Gray and Sawa), St Michael's Hospital and the University of Toronto.

Arch Neurol. 1987;44(4):376-378. doi:10.1001/archneur.1987.00520160018007

• A systematic psychiatric evaluation was performed on 100 consecutive patients attending a multiple sclerosis clinic. Forty-two percent of the patients had lifetime history of depression, and 13% fulfilled criteria for manic-depressive illness. Only 28% of the patients had no psychiatric diagnosis. The relationship of psychiatric disorder to neurologic dysfunction and other aspects of multiple sclerosis are presented. Clinical and theoretical implications of these findings are discussed.