November 1987

Mollaret's Meningitis Associated With Acute Epstein-Barr Virus Mononucleosis

Author Affiliations

From the Infectious Diseases Unit, Department of Medicine, University of Rochester (NY) School of Medicine and Dentistry.

Arch Neurol. 1987;44(11):1204-1205. doi:10.1001/archneur.1987.00520230084023

• A 19-year-old man developed recurrent aseptic meningitis (Mollaret's meningitis) during the course of acute Epstein-Barr virus infectious mononucleosis. Serum contained heterophil antibody and Epstein-Barr virus—specific antibodies characteristic of acute infection. Seven brief episodes of aseptic meningitis were documented over the following one-year period, in each case with a polymorphonuclear pleocytosis in the cerebrospinal fluid. Acute infection with Epstein-Barr virus, or subsequent reactivation of virus, may account for some cases of Mollaret's meningitis.